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Total 144 results found since Jan 2013.
Sporozoite immunization: Innovative Translational Science to Support the Fight against malaria
Expert Rev Vaccines. 2023 Aug 11. doi: 10.1080/14760584.2023.2245890. Online ahead of print.ABSTRACTINTRODUCTION: Malaria, a devastating febrile illness caused by protozoan parasites, sickened 247,000,000 people in 2021 and killed 619,000, mostly children and pregnant women in sub-Saharan Africa. A highly effective vaccine is urgently needed, especially for Plasmodium falciparum (Pf), the deadliest human malaria parasite.AREAS COVERED: Sporozoites (SPZ), the parasite stage transmitted by Anopheles mosquitoes to humans, are the only vaccine immunogen achieving > 90% efficacy against Pf infection. This review describes &g...
Source: Cancer Control - August 12, 2023 Category: Cancer & Oncology Authors: Thomas L Richie L W Preston Church Tooba Murshedkar Peter F Billingsley Eric R James Mei-Chun Chen Yonas Abebe None Natasha Kc Sumana Chakravarty David Dolberg Sara A Healy Halimatou Diawara Mahamadou S Sissoko Issaka Sagara David M Cook Judith E Epstein Source Type: research
Analysis of hepatocellular carcinoma associated with hepatitis B virus
J Cell Mol Med. 2023 Jul 30. doi: 10.1111/jcmm.17867. Online ahead of print.ABSTRACTThe hepatitis B virus (HBV) is considered one of the main driving forces in the development of hepatocellular carcinoma (HCC). Human HBV is a partially double-stranded DNA (dsDNA) virus consisting of approximately 3.2 kbp. HBV predominantly infects hepatocytes via the receptor sodium taurocholate cotransporting polypeptide (NTCP) and coreceptor hepatic proteoglycan. The replication of HBV in hepatocytes leads to apoptosis while simultaneously leading to cirrhosis and cancer. Although the integration of dsDNA into the hepatocyte genome seems...
Source: J Cell Mol Med - July 30, 2023 Category: Molecular Biology Authors: Litao Zheng Source Type: research
Maternal immunization during the second trimester with BNT162b2 mRNA vaccine induces a robust IgA response in Human Milk: A prospective cohort study
CONCLUSIONS AND RELEVANCE: Our study provides evidence that administering the mRNA-vaccine to pregnant females during the second trimester leads to increased levels of vaccine-specific IgA during lactation. Considering the significance of human-milk IgA in mucosal tissues and its prevalence throughout lactation, it is reasonable to recommend maternal immunization with the BNT162b2 mRNA-vaccine during the second trimester.PMID:37479184 | DOI:10.1016/j.ajcnut.2023.07.013
Source: Cancer Control - July 21, 2023 Category: Cancer & Oncology Authors: Aya Kigel Sharon Vanetik Laurence Mangel Gal Friedman Chen Nozik Camilla Terracina David Taussig Yael Dror Hadar Samra Dror Mandel Ronit Lubetzky Yariv Wine Source Type: research
Head-to-head immunogenicity comparison of an Escherichia coli-produced 9-valent human papillomavirus vaccine and Gardasil 9 in women aged 18-26 years in China: a randomised blinded clinical trial
This study aimed to compare the immunogenicity of the E coli-produced HPV 9-valent vaccine Cecolin 9 (against HPV 6, 11, 16, 18, 31, 33, 45, 52, and 58) with Gardasil 9.METHODS: This was a randomised, single-blind trial conducted in China. Healthy non-pregnant women aged 18-26 years, who were not breastfeeding and with no HPV vaccination history, were enrolled in the Ganyu Centre for Disease Control and Prevention (Lianyungang City, Jiangsu Province, China). Women were stratified by age (18-22 years and 23-26 years) and randomly assigned (1:1) using a permutated block size of eight to receive three doses of Cecolin 9 or Ga...
Source: Cancer Control - July 20, 2023 Category: Cancer & Oncology Authors: Feng-Cai Zhu Guo-Hua Zhong Wei-Jin Huang Kai Chu Li Zhang Zhao-Feng Bi Kong-Xin Zhu Qi Chen Ting-Quan Zheng Ming-Lei Zhang Sheng Liu Jin-Bo Xu Hong-Xing Pan Guang Sun Feng-Zhu Zheng Qiu-Fen Zhang Xiu-Mei Yi Si-Jie Zhuang Shou-Jie Huang Hui-Rong Pan Ying-Y Source Type: research
Measurement of Sex and Gender Identity in the Behavioral Risk Factor Surveillance System Survey, 2014 to 2020
This study examines BRFSS participant responses to gender identity and sex questions, 2014-2020. About 70% of participants who identified as transgender male-to-female reported male sex while 30% reported female sex. Participants who identified as transgender female-to-male reported female sex about 65% of the time and reported male sex 35% of the time. Despite changes in sex question wording, these percentages were consistent over time. Reported sex is used in computing health-related variables and in routing participants to questions about birth control, pregnancy, HPV vaccines, and cancer screenings. Without better meas...
Source: Journal of Health Care for the Poor and Underserved - July 19, 2023 Category: International Medicine & Public Health Authors: Jenine K Harris Odalis Hernandez Source Type: research
